The following recommendations for the use of PLUSET for the induction of superovulation with adequate response should be followed:Ī.The donor animal must have had at least one normal oestrous cycle prior to the initiation of PLUSET treatment.ī.The donor animal should not have any signs of clinical illness when treatment with PLUSET begins. To induce superovulation in reproductively mature heifers or cows. Kinetic studies of FSH and LH in the bloodstream of bovine has shown a half-life of 150 minutes for FSH and a half-life of 40 minutes for LH. PLUSET is manufactured in a method chosen to ensure that the defined level of LH content is consistently mantained. Thus, given that it influences the activity of FSH, it is important to have a defined level of LH present.
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The pituitary hormone extract contains variable levels of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).Ĭlearly in order to obtain proper and effective superovulation which provides satisfactory results involving a high number of living embryos, it is necessary to carry out a treatment that guarantees the activation and progress of multiple follicle maturation in the most “physiological” and repeatable way possible. Ovarian stimulation with exogenous Follicle-Stimulating Hormone (FSH) allows a greater number of ova to be produced than normally produced in a single reproductive cycle. In the absence of an International Standard for the porcine gonadotrophin, dosing is carried out using the International Standard for human urine FSH and LH. The use of standardized concentrations for both gonadotrophins guarantees a consistent quality of the product and eliminates possible variability in effectiveness from one lot to another. PLUSET is a mixture of swine pituitary gonadotrophins used for the induction of multiple ovulations (superovulation). For further information about unapproved drugs, click here.
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PLUSET- porcine follicle stimulating hormone, porcine luteinizing hormoneĭisclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA.